I've been using this software for years.  Today I ran it and it said "There is no disc in the drive.  Please insert a disk into Drive Device/hardisk/DR2".

 

I have tried running ADWC several times, including downloading it.  Checked my computer drives (C & D (data)) and they are fine.  Have no idea what this means.  To add insult to injury the only way to delete this popup is to use file manager and sometimes even that doesn't work, I have to restart my computer.

Help would be appreciated.